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Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss ''Huperzia serrata''〔 and in varying quantities in other ''Huperzia'' species, including ''H. elmeri'', ''H. carinat'', and ''H. aqualupian''. Huperzine A has been found, through multiple studies, to be effective as a medicine for helping people with neurological conditions such as Alzheimer's disease, but the meta-analysis of those studies concluded that they were poor quality and the findings should be interpreted with caution. ==Pharmacological effects== Huperzine A is extracted from ''Huperzia serrata''. It is a reversible acetylcholinesterase inhibitor and NMDA receptor antagonist that crosses the blood-brain barrier. The structure of the complex of huperzine A with acetylcholinesterase has been determined by X-ray crystallography (PDB code: (1VOT ); (see the 3D structure )). For some years, huperzine A has been investigated as a possible treatment for diseases characterized by neurodegeneration – particularly Alzheimer's disease.〔 A 2013 meta-analysis found that huperzine A may be efficacious in improving cognitive function, global clinical status, and activities of daily living for individuals with Alzheimer’s disease. However, due to the poor size and quality of the clinical trials reviewed, huperzine A should not be recommended as a treatment for Alzheimer’s disease until further high quality studies confirm its beneficial effects. Huperzine A is also marketed as a dietary supplement with claims made for its ability to improve memory and mental function. Huperzine A may also have a possible role in the treatment of myasthenia gravis. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Huperzine A」の詳細全文を読む スポンサード リンク
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